In the latest predictions for NFL Week 16 against the spread, the Detroit Lions and Green Bay Packers bounce back from previous losses while teams in the AFC West, including the Los Angeles Chargers, Denver Broncos, and Kansas City Chiefs, secure victories.
Week 14 brought another round of unexpected results, showcasing the unpredictable nature of the league as the regular season nears its conclusion. With only three weeks left in the 2025 season, here are the fearless forecasts for the upcoming matchups.
Key Matchups and Predictions
In the Game of Midweek, the Los Angeles Rams visit the Seattle Seahawks on Thursday night. The Rams are finishing drives effectively thanks to their running game and tight ends. Meanwhile, the Seahawks have struggled offensively, which could be pivotal. The Rams are expected to emerge victorious with a score of 27-23, covering the spread.
For the Game of the Week, the Pittsburgh Steelers travel to face the Lions, who are favored by seven points. While Aaron Rodgers and his receiving corps will challenge a weakened Detroit defense, the Lions” run game led by Jahmyr Gibbs and David Montgomery will likely guide them to a 30-24 victory, although they may not cover the spread.
Locks and Upsets
The Philadelphia Eagles are predicted to defeat the Washington Commanders by six points in a matchup on Saturday. With a revitalized offense after a strong showing against the Las Vegas Raiders, the Eagles should win decisively, projected at 34-17 and covering the spread.
In an upset alert, the New England Patriots are expected to defeat the Baltimore Ravens by 2.5 points. Despite a tough outing against the Buffalo Bills, Drake Maye is anticipated to bounce back, leading the Patriots to a 27-24 win.
Additional Game Predictions
The Packers, facing the Chicago Bears, are favored by 1.5 points. After a tough loss in Denver, they are expected to win 20-17, covering the spread. The Buffalo Bills are also projected to defeat the Cleveland Browns 24-10, covering a 10-point spread.
The Los Angeles Chargers will face a struggling Dallas Cowboys team, with a projected score of 24-17 in favor of the Chargers. The Kansas City Chiefs are set to face the Tennessee Titans and are expected to win 27-20, covering the spread as well.
As the season continues, these matchups will be critical for playoff positioning and team momentum heading into the final stretch.
