As we dive into Week 10 of the 2025 NFL season, the matchups promise excitement and intrigue. The highlight of the week features a Sunday afternoon clash between the New England Patriots and the Tampa Bay Buccaneers.
In a Thursday night showdown, the Las Vegas Raiders (2-6) will face the Denver Broncos (7-2). The Raiders are struggling, having dropped three consecutive road games, and will be without key receiver Jakobi Meyers, who was traded to the Jaguars. Although they have some talent in Brock Bowers and Ashton Jeanty, it may not be enough to challenge a solid Denver defense. The Broncos, despite a pair of double-digit wins this season, should secure a comfortable victory.
GIVEMESPORT Pick: Denver Broncos
The game between the Atlanta Falcons (3-5) and the Indianapolis Colts (7-2) will take place in Berlin, Germany. This matchup could be closer than it appears. The Falcons possess a strong defense that limits passing yards but struggle against the run, facing a formidable opponent in Jonathan Taylor. Expect the Colts to score, but the Falcons are not to be underestimated.
GIVEMESPORT Pick: Indianapolis Colts
Next, the Patriots (7-2) will visit the Buccaneers (6-2). New England is riding a six-game winning streak and leads the AFC East. Conversely, Tampa Bay has been effective under Baker Mayfield, who is making a case for MVP. Coming off a bye week, the Buccaneers will look to capitalize on their home advantage and may neutralize the Patriots” run game, challenging quarterback Drake Maye to step up.
GIVEMESPORT Pick: New England Patriots
The Buffalo Bills (6-2) are set to visit the struggling Miami Dolphins (2-7). The Bills are fresh off a significant win against the Chiefs, and quarterback Josh Allen”s impressive record against Miami gives them confidence. Tua Tagovailoa”s poor history against Buffalo suggests this game won”t be competitive.
GIVEMESPORT Pick: Buffalo Bills
In a matchup featuring the Baltimore Ravens (3-5) against the Minnesota Vikings (4-4), the Ravens are now stronger with a healthy Lamar Jackson. The Vikings have shown inconsistency, and while they had a notable win over the Lions, they need more consistency to challenge Baltimore.
GIVEMESPORT Pick: Baltimore Ravens
The Cleveland Browns (2-6) will face the New York Jets (1-7), who are in a rebuilding phase after trading several key players. Despite their own struggles, the Browns should have the upper hand due to their overall talent and defense.
GIVEMESPORT Pick: Cleveland Browns
Meanwhile, the New York Giants (2-7) visit the Chicago Bears (5-3). The Bears have been inconsistent but continue to find ways to win, whereas the Giants have faced setbacks, particularly with the injury to Cam Skattebo. Caleb Williams will need to make plays to keep the Giants competitive.
GIVEMESPORT Pick: Chicago Bears
In another intriguing contest, the New Orleans Saints (1-8) will take on the Carolina Panthers (5-4). The Panthers have improved recently, securing four wins in their last five games. Tyler Shough will start for the Saints, but expectations are low for a victory.
GIVEMESPORT Pick: Carolina Panthers
The Jacksonville Jaguars (5-3) will visit the Houston Texans (3-5) in what could be a defensive battle. With C.J. Stroud sidelined, Davis Mills will start for the Texans. The Jaguars have added talent in Jakobi Meyers and should be able to secure a win.
GIVEMESPORT Pick: Jacksonville Jaguars
The Arizona Cardinals (3-5) will take on the Seattle Seahawks (6-2) at home, where Seattle has a strong record. The Cardinals have looked better with Jacoby Brissett, but the Seahawks are considered Super Bowl contenders, making this matchup challenging for Arizona.
GIVEMESPORT Pick: Seattle Seahawks
In a key matchup, the Los Angeles Rams (6-2) will face the San Francisco 49ers (6-3). These matchups are often tightly contested, with the Rams looking to avenge an earlier loss to San Francisco. The Rams are gaining momentum, making this a crucial game for both teams.
GIVEMESPORT Pick: Los Angeles Rams
The Detroit Lions (5-3) will aim to bounce back against the Washington Commanders (3-6). Following a loss to the Vikings, the Lions are expected to dominate a Commanders team that is struggling with injuries.
GIVEMESPORT Pick: Detroit Lions
Finally, the Pittsburgh Steelers (5-3) will face the Los Angeles Chargers (6-3) in Sunday Night Football. The Steelers have had difficulties in prime time, while the Chargers are dealing with injuries. Pittsburgh”s defense showed promise last week, but they may find it challenging to maintain that level of play.
GIVEMESPORT Pick: Los Angeles Chargers
In a Monday night matchup, the Philadelphia Eagles (6-2) will face the Green Bay Packers (5-2-1). The Packers are facing challenges with injuries, particularly losing star tight end Tucker Craft. Meanwhile, the Eagles are looking strong after making defensive improvements.
GIVEMESPORT Pick: Philadelphia Eagles
