The stage is set for a pivotal NFC West clash as the Los Angeles Rams take on the San Francisco 49ers in Week 10 of the 2025 NFL season. Both teams are vying for playoff positioning, and a win against a divisional rival would serve as a significant morale boost. The game kicks off at 4:25 PM ET.
Looking at the projected starting lineups, the Rams will feature quarterback Matthew Stafford leading the offense alongside wide receivers Davante Adams and Jordan Whittington. The offensive line includes Alaric Jackson at left tackle and Steve Avila at left guard, providing protection for Stafford. Running back Kyren Williams will aim to establish a ground game against a tough 49ers defense.
On the defensive side, the Rams are expected to showcase outside linebacker Byron Young and defensive end Braden Fiske. Their ability to pressure 49ers quarterback Brock Purdy will be crucial for the Rams” success. The secondary, featuring cornerback Emmanuel Forbes Jr. and safety Quentin Lake, will need to contain the 49ers” potent passing attack.
For the 49ers, Brock Purdy will command the offense, with Christian McCaffrey expected to play a key role in both the rushing and passing games. The offensive line, anchored by Trent Williams, will aim to protect Purdy and open lanes for McCaffrey and fullback Kyle Juszczyk.
Defensively, the 49ers will look to disrupt the Rams with a front line that includes Mykel Williams and Kevin Givens. The linebacker corps, led by Tatum Bethune, and a secondary featuring Renardo Green will be tasked with keeping the Rams” aerial attack in check.
Both teams come into this game with strong motivations. The 49ers, currently at a 6-3 record, are looking to solidify their playoff position after overcoming injuries to key players. Meanwhile, the Rams are eager to avenge their earlier defeat to the 49ers in Week 5, where they lost in overtime.
This matchup not only has playoff implications but could also influence the standings in the highly competitive NFC West. Fans can expect an exciting showdown as both teams strive for victory.
